Distinguishing direct versus indirect transcription factor-DNA interactions
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چکیده
منابع مشابه
1 “ Distinguishing direct versus indirect transcription factor - DNA interactions ”
P<P Published online August 3, 2009 in advance of the print journal. Open Access This manuscript is Open Access. Preprint Accepted likely to differ from the final, published version. Peer-reviewed and accepted for publication but not copyedited or typeset; preprint is service Email alerting click here top right corner of the article or Receive free email alerts when new articles cite this artic...
متن کاملDistinguishing Direct versus Indirect Transcription Factor-DNA Interactions
Transcriptional regulation is largely enacted by transcription factors (TFs) binding DNA. Large numbers of TF binding motifs have been revealed by ChIP-chip experiments followed by computational DNA motif discovery. However, the success of motif discovery algorithms has been limited when applied to sequences bound in vivo (such as those identified by ChIP-chip) because the observed TF-DNA inter...
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Computer Science) Protein-DNA Binding: Discovering Motifs and Distinguishing Direct From Indirect Interactions by Raluca M. Gordân Department of Computer Science Duke University Date: Approved: Alexander J. Hartemink, Advisor Uwe Ohler Bruce R. Donald David M. MacAlpine An abstract of a dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in t...
متن کاملGenomic studies of transcription factor-DNA interactions.
A central issue in the regulation of gene expression is the physical association of transcription factors with relevant promoter sequences. Recently, technological advances have allowed researchers to analyze these processes on a genomic scale. In particular, the combination of the chromatin immunoprecipitation (ChIP) technique with microarray analysis (the 'ChIP to chip' experiment) is providi...
متن کاملDistinguishing direct from indirect interactions in oscillatory networks with multiple time scales.
We propose a method to infer the coupling structure in networks of nonlinear oscillatory systems with multiple time scales. The method of partial phase synchronization allows us to infer the coupling structure for coupled nonlinear oscillators with one well-defined time scale. The case of oscillators with multiple time scales has remained a challenge until now. Here, we introduce partial recurr...
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ژورنال
عنوان ژورنال: Genome Research
سال: 2009
ISSN: 1088-9051
DOI: 10.1101/gr.094144.109